Olfactory Epithelium as an Infinitive Source of Neural Stem Cells for Derivation of Inner Ear Hair Cells
نویسندگان
چکیده
منابع مشابه
Effect of Neurotrophin-3 on Differentiation of Rat Hair Follicle Stem Cells into Neural Like Cells
Purpose: The aim of this study was to evaluate the effect of NT-3 on the decrease of the differentiation time of bulge stem cells of rat hair follicle from neuron like cells.Materials and Methods: The bulge region of the rat whisker was isolated from and cultured in DMEM/F12 supplemented with epidermal growth factor (EGF) in 3 groups for 7, 8 and 9 days .Then 10 ng/ml NT-3 was added to each gro...
متن کاملOrigin of inner ear hair cells: morphological and functional differentiation from ciliary cells into hair cells in zebrafish inner ear.
Auditory and vestibular functions in vertebrates depend on the transduction of sound vibration or head acceleration into electrical responses in inner ear hair cells. Mechanoelectrical transduction occurs at the tip of stereocilia, which are polarized to form an orientational arrangement that determines directional sensitivity. It remains to be clarified when and how premature hair cells acquir...
متن کاملWisdom Tooth as the Source of Stem Cells
Background Wisdom teeth are usually removed as a routine procedure for therapeutic or prophylactic reasons. Developing wisdom teeth are easy accessible source of stem cells during the adulthood which could be obtained. Methods Search of the PubMed for stem cells and tooth was done. An inclusion criterion was extract of stem cells from wisdom tooth. Results Stem cells can be obtained fro...
متن کاملStem cells for the replacement of inner ear neurons and hair cells.
Stem cells in the nervous system have some capacity to restore damaged tissue. Proliferation of stem cells endows them with self-renewal ability and accounts for in vitro formation of neurospheres, clonally derived colonies of floating cells. However, damage to the nervous system is not readily repaired, suggesting that the stem cells do not provide an easily recruited source of cells for regen...
متن کاملGeneration of inner ear hair cells in vitro from mouse embryonic stem cells
Embryonic stem cells (ESCs) are key tools for genetic engineering and development of stem cell-based therapies. The investigation of ESCs pluripotency and early lineage commitment is an essential precondition for its translational use. In this study, we explored the ability of mouse ESC to differentiate into inner ear hair cell lineages. Mouse embryonic stem cells (E14TG2A) were cultured on pri...
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ژورنال
عنوان ژورنال: International Journal of Morphology
سال: 2017
ISSN: 0717-9502
DOI: 10.4067/s0717-95022017000200004